Immunohistochemical Evaluation of COL11A1 and FGD3 Expression in Invasive Breast Cancer

Background: Collagen type XI, alpha 1 (COL11A1) is a minor component of extracellular matrix and its overexpression associated with tumoral progression poorer outcome in several human cancers; data on breast cancer are promising but scarce. FGD3 expression has been shown to be strong independent prognostic factor cancer. The aim our study was investigate whether COL11A1 correlates other classic pathologic factors including expression, as well clinical outcome, evaluate potential use patients. Methods: We evaluated by immunohistochemistry we studied the relationship between this protein traditional factors, patients’ outcome. Results: found that higher stromal tumour grade (G3) (p = 0.001), Ki67 proliferation index 0.006), more advanced AJCC stage 0.031) lower 0.039). In case-control analysis, observed patients high-COL11A1 had risk recurrence (OR 2.0) dying disease 2.0). Patients high-COL11A1-expressing tumours shorter disease-free survival overall (difference not significant). There linear positive correlation epithelial cells surrounding (r 0.247, p 0.04). Conclusion: Our findings suggest may represent marker aggressiveness invasive detection warrants further larger series possible practice.